Poverty is a pain, but no disgrace

The man groaned in pain

It's painful to keep sitting for hours

The work of art, I decided, was the final product of human activity, and the final justification for all the misery, the endless toil and the frustrated strivings of humanity

The soldier groaned with pain

His son's criminal activities caused him great pain

He lay in agony until the doctor arrived

He held back a cry of agony

The treatment prolonged the agony

He cried out in pain